Clinical Trials

Anxiety

Bipolar disorder

Cancer, breast

Cancer, lung, non-small-cell

Cardiovascular disease

Cellulite

Cognition

Dental plaque

Diabetes

Fatty liver disease: see steatohepatitis

Gingivitis

Gout

H. pylori (Helicobacter pylori infection)

Heart/Arrhythmia/Bradycardia

Irritable bowel syndrome (IBS)

Laryngopharyngeal reflux (Silent reflux)

Metabolic syndrome

Parkinson’s disease

Rare diseases

Steatohepatitis

Stroke

Obesity & weight management

Ulcerative colitis

Anxiety

Lavender oil for anxiety: a softgel preparation produced decrease in anxiety symptoms, starting with 2 weeks after beginning of use (Abstract)

Bipolar Disorder

Withania somnifera (ashwagandha): appeared to improve auditory-verbal working memory, a measure of reaction time, and a measure of social cognition (Abstract)

Cancer, breast

Withania somnifera (ashwagandha): reduced chemotherapy-induced fatigue and prolonged survival (Abstract)

Cancer, Lung, non-small-cell

Astragalus spp.: may benefit the patients via increasing the therapeutic effectiveness and reducing the toxicity of radiotherapy (Abstract, Free full text)

Cardiovascular disease

β-Conglycinin (a protein from soya): at a low dose of 2-3 g a day, significantly decreased serum TAG and LDL-cholesterol levels in menopausal women (Abstract)

Curcumin: reduction of atherosclerosis risk in subjects with type 2 diabetes (Abstract)

Dichrostachys glomerata [an herb from Africa] aqueous extract: reduction of cardiovascular disease risk factors associated with metabolic syndrome in obese subjects (Abstract, Free full text)

Fruit/berry/vegetable concentrate (capsules): reduction of oxidation and inflammation markers and improvement of microcirculation parameters in obese women (Abstract, Free full text)

Cellulite

Aronia spp. (chokeberry), juice: reduces edema in cellulite (Abstract)

Cognition

Ginkgo biloba: no discernible positive cognition effects found in healthy individuals (Abstract)

Dental Plaque

A herbal mouthwash (Freshol): equal to or more effective than chlorhexidine in reducing the salivary Streptococcus mutans count, improving plaque status, in children (Abstract, Free full text)

Calendula officinalis, tincture (2 mL, diluted in 6 mL of distilled water), mouthwash: effective in reducing dental plaque and gingivitis adjunctive to scaling (Abstract)

Diabetes

Curcumin: reduction of atherosclerosis risk in subjects with type 2 diabetes (Abstract)

Juglans regia (common walnut) leaves, aqueous extract: significantly decreased serum fasting HbA1C and blood glucose levels and increased insulin levels in patients with type 2 diabetes (Abstract, Free full text); significantly decreased total cholesterol and triglyceride levels in patients with type 2 diabetes (Abstract)

Nigella sativa (black cumin) seeds: reductions in fasting and 2-hour postprandial blood glucose, glycosylated hemoglobin (HbA1), and insulin resistance measured by HOMA2 method (Abstract)

Tianqi (traditional Chinese herbal formula): reduction of progression from impaired glucose tolerance to diabetes (Abstract)

Trigonella foenum-graecum (fenugreek): beneficial effects on glycemia are supported; significant effects of medium and high doses in persons with diabetes (Abstract, Free full text)

Gingivitis

A herbal mouthwash (Freshol): equal to or more effective than chlorhexidine in improving gingival status in children (Abstract, Free full text)

Calendula officinalis, tincture (2 mL, diluted in 6 mL of distilled water), mouthwash: effective in reducing dental plaque and gingivitis adjunctive to scaling (Abstract)

Matricaria  chamomilla (chamomile), Punica granatum (pomegranate), extracts: as a mouth rinse, similar to chlorhexidine 0.12% solution in reducing gingival bleeding (Abstract)

Gout

Traditional Chinese herbal decoctions for the treatment of gout: equal to Western medicine in terms of healing, but superior in controlling adverse drug effects (Abstract, Free full text)

H. pylori (Helicobacter pylori infection)

Nigella sativa (black cumin) seed: comparable with triple therapy (clarithromycin, amoxicillin, omeprazole) (Abstract, Free full text)

Heart/Arrhythmia/Bradycardia

Shensongyangxin (traditional polyherbal formulation): increase in heart rate in patients with bradycardia (Free full text)

Irritable bowel syndrome (IBS)

Polyherbal traditional Iraqi remedy (Mentha longifolia, Cyperus rotundus, and Zingiber officinale): significantly improved irritable bowel syndrome symptoms after 8 weeks of treatment (Abstract)

Laryngopharyngeal reflux (Silent reflux)

Rikkunshito (aka Liu Jun Zi Tang, Six-Gentleman Formula): stimulates gastric emptying in patients with proton-pump inhibitor-refractory laryngopharyngeal reflux (Abstract, Free full text)

Metabolic Syndrome

Barberry (three capsules a day for six weeks) reduced total and LDL-cholesterol while increasing HDL-cholesterol, reduced hs-CRP, and decreased the antibodies to HSP 27 and 60 in patients with metabolic syndrome (Abstract)

Parkinson’s disease

Liu Jun Zi Tang (Rikkunshi-to, Six-Gentleman Formula): amelioration of gastroparesis in Parkinson’s disease (Abstract)

Rare diseases

Triptolide (a compound from Trypterigium wilfordii, Thunder God vine): effective in relieving short-term symptoms in children with moderately severe Henoch-Schönlein purpura nephritis (Abstract)

Steatohepatitis

Silymarin in the treatment of non-alcoholic steatohepatitis: after 8 weeks treatment, the patients’ hepatic enzymes levels were significantly reduced, compared to the control group (Abstract, Free full text)

Stroke

Polyherbal traditional Chinese preparation MLC601: reduces vascular events after stroke (Abstract)

Weight management & Obesity

Combination of capsaicinoids (from Capsicum sp.), epigallocatechin gallate (EGCG, from green tea), piperin (from Piper nigrum), and L-carnitine: significantly increased satiety in overweight subjects, in comparison with placebo group (Abstract)

Dichrostachys glomerata [an herb from Africa] aqueous extract: reduction of cardiovascular disease risk factors associated with metabolic syndrome in obese subjects (Abstract, Free full text)

Fruit/berry/vegetable concentrate (capsules): reduction of oxidation and inflammation markers and improvement of microcirculation parameters in obese women (Abstract, Free full text)

Sphaeranthus indicus and Garcinia mangostana (mangosteen), extracts: use for weight management (Abstract, Free full text)

Ulcerative colitis

A combination of myrrh, chamomile flowers (dry extract), and coffee charcoal: equal to mesalazine in maintaining remission in patients with ulcerative colitis (Abstract)

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2 responses to “Clinical Trials

  1. Thank you for following my blog, Pavel. Yours is certainly very educational.
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    Dave Lambert
    David’s Delicious Chocolates
    The Chocolate Postman Delivers

  2. Thank you, Dave! What could I do to give you the permission? I will be glad if you link our blogs! 🙂 Please, you can use my link https://herbanaut.wordpress.com/

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